Hydroxyamine hydrochloride → HCID 178439788, compound

HRID 612966Notes

Reaction equation

C([O:3][C:4](=O)[CH:5]([C:9](=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[N:12][CH:11]=1)[CH:6]([CH3:8])[CH3:7])C.Cl.[NH2:19]O.C[O-].[Na+]>>[OH:3][C:4]1[C:5]([CH:6]([CH3:8])[CH3:7])=[C:9]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[O:16][N:19]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 10942334Sodium Methoxide

HCID 53640330HCID 53640330, compound

Product 1

HCID 178439788HCID 178439788, compoundYield 23%

Procedure

2-Nicotinoylisovaleric acid ethyl ester (0.76 g), hydroxylamine hydrochloride (0.46 g) and sodium methoxide (28% methanol solution, 3.1 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 8(b) to obtain the title compound (0.15 g, 23%) as colorless crystals.

Sources & evidence

ORD record: ord-64da0e24ee5e4e77b755434508f36e44
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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