反应详情

A mixture of 8-amino-3-bromoquinoline (200 mg) and sodium thiomethoxide (109 mg) in N,N-dimethylformamide (2 ml) was stirred at ambient temperature for 2 days. After diluted with ethyl acetate, the resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on silica gel (n-hexane-ethyl acetate) to give 8-amino-3-methylthioquinoline (113 mg) as an oil.

1. washthe resulting mixture was washed with water and brine
2. dry with materialdried over anhydrous sodium sulfate
3. customevaporated in vacuo
4. customThe residue was purified by chromatography on silica gel (n-hexane-ethyl acetate)