Sodium methanethiolate → HCID 19592663, 화합물

HRID 613465노트

반응식

HRID 613465 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8](Br)=[CH:7]2.[CH3:13][S-:14].[Na+]>CN(C)C=O.C(OCC)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([S:14][CH3:13])=[CH:7]2

참가 물질

5

반응물 2

HCID 4378561Sodium methanethiolateHCID 151125453-Bromoquinolin-8-amine

생성물 1

HCID 19592663HCID 19592663, 화합물수율 66.2%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 8-amino-3-bromoquinoline (200 mg) and sodium thiomethoxide (109 mg) in N,N-dimethylformamide (2 ml) was stirred at ambient temperature for 2 days. After diluted with ethyl acetate, the resulting mixture was washed with water and brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by chromatography on silica gel (n-hexane-ethyl acetate) to give 8-amino-3-methylthioquinoline (113 mg) as an oil.

후처리

  1. washthe resulting mixture was washed with water and brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated in vacuo
  4. customThe residue was purified by chromatography on silica gel (n-hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-802c2d8881664f5886a4efecce353081
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008230

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