HCID 19593011, compound → HCID 19592405, compound

HRID 613509Notes

Reaction equation

HRID 613509 reaction equation
C([CH2:4][C:5]1[C:14]2[C:9](=[C:10]([NH:15][C:16](=[O:25])[C:17]3[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:24])[CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[C:26]([O:28][CH2:29][CH3:30])=[O:27])(O)=O>ClCCCl>[Cl:24][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([Cl:23])[C:17]=1[C:16]([NH:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[N:8]=[CH:7][C:6]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:5]2[CH3:4])=[O:25]

Participants

3

Reactant 1

HCID 19593011HCID 19593011, compound

Product 1

HCID 19592405HCID 19592405, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A suspension of 4-carboxymethyl-8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonylquinoline (2-5 g) in 1,2-dichloroethane (60 ml) was refluxed for 14 hours. The solvent was removed under reduced pressure and the residual solid was treated with hot ethanol (45 ml) to afford 8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonyl-4-methylquinoline (2.08 g) as a colorless prism.

Workup

  1. temperaturewas refluxed for 14 hours
  2. customThe solvent was removed under reduced pressure
  3. additionthe residual solid was treated with hot ethanol (45 ml)

Sources & evidence

ORD record
ord-a743fad93d32411293beb7ee3ef5353d
Source dataset
uspto-grants-1999_12
Patent number
US06008230

Reaction notes

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