Hydrochloric Acid → 2-(2-Aminoethyl)-1H-isoindole-1,3(2H)-dione--hydrogen chloride (1/1)

HRID 613654Notes

Reaction equation

HRID 613654 reaction equation
C(OC([NH:8][CH2:9][CH2:10][N:11]1[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]2[C:12]1=[O:21])=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:8][CH2:9][CH2:10][N:11]1[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]2[C:12]1=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11483141tert-Butyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate

Product 1

HCID 220638492-(2-Aminoethyl)-1H-isoindole-1,3(2H)-dione--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of N-(2-tert-butoxycarbonylaminoethyl)phthalimide (2.5 g) and 4N solution of hydrogen chloride in ethyl acetate (25 ml) was stirred for 1 hour at ambient temperature. The resulting precipitates were collected by filtration and washed with ethyl acetate to give N-(2-aminoethyl)phthalimide hydrochloride (1.89 g) as colorless crystals.

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-088d5612d5cc4277bcff6be687a19dbe
Source dataset
uspto-grants-1999_12
Patent number
US06008229

Reaction notes

Loading…