Cyanide → HCID 21329842, compound

HRID 614024Notes

Reaction equation

HRID 614024 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:5]([N:8]=[C:9]=[O:10])([CH3:7])[CH3:6].[C-]#N.[CH2:17]([NH:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[CH3:18]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:5]([NH:8][C:9](=[O:10])[N:19]([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[CH2:17][CH3:18])([CH3:7])[CH3:6]

Participants

5

Reactant 3

HCID 5975CyanideHCID 21609N-Ethyl cyclohexylamineHCID 213298621,2-Dichloro-4-(2-isocyanatopropan-2-yl)benzene

Product 1

HCID 21329842HCID 21329842, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 2.3 g of 3,4-dichloro-α,α-dimethylbenzyl isocyanate, prepared from the corresponding cyanide in the same way as in Synthesis Example 1, in 10 ml of chloroform was added to 1.5 g of N-ethylcyclohexylamine. The solvent was then removed by distillation and the resulting white crystals were recrystallized from a mixture of benzene-n-hexane to obtain 2.6 g of the title compound.

Workup

  1. customThe solvent was then removed by distillation
  2. customthe resulting white crystals were recrystallized from a mixture of benzene-n-hexane

Sources & evidence

ORD record
ord-2f7022194ad341769555256ad35a1077
Source dataset
uspto-grants-1979_03
Patent number
US04143061

Reaction notes

Loading…