Dimethylformamide → 5-chloro-2-[3-(2-phthalimidoacetamidomethyl)-5-propargyloxymethyl-4H-1,2,4-triazol-4-yl]-benzophenone

HRID 614059Notes

Reaction equation

HRID 614059 reaction equation
Br.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([N:17]2[C:21]([CH2:22][O:23][CH2:24][C:25]#[CH:26])=[N:20][N:19]=[C:18]2[CH2:27][NH2:28])=[C:7]([CH:16]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9].[C:29]1(=[O:43])[N:33]([CH2:34][C:35](Cl)=[O:36])[C:32](=[O:38])[C:31]2=[CH:39][CH:40]=[CH:41][CH:42]=[C:30]12.CN(C)C=O.C(=O)(O)[O-].[Na+]>C1C=CC=CC=1.O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([N:17]2[C:21]([CH2:22][O:23][CH2:24][C:25]#[CH:26])=[N:20][N:19]=[C:18]2[CH2:27][NH:28][C:35](=[O:36])[CH2:34][N:33]2[C:32](=[O:38])[C:31]3=[CH:39][CH:40]=[CH:41][CH:42]=[C:30]3[C:29]2=[O:43])=[C:7]([CH:16]=1)[C:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:9]

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 516892Sodium BicarbonateHCID 213257145-chloro-2-(3-aminomethyl-5-propargyloxymethyl-4H-1,2,4-triazol-4-yl)-benzophenone hydrobromide

Product 1

HCID 213257355-chloro-2-[3-(2-phthalimidoacetamidomethyl)-5-propargyloxymethyl-4H-1,2,4-triazol-4-yl]-benzophenone

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 962WaterSolvent

Procedure

A mixture of the above product (817 mg) and 27.5% hydrogen bromide/acetic acid (3 ml) is stirred at room temperature for 1.5 hours. The resultant solution is mixed with dry ether (30 ml) to give a precipitate. The precipitate is washed with dry ether (20 ml) twice to give 5-chloro-2-(3-aminomethyl-5-propargyloxymethyl-4H-1,2,4-triazol-4-yl)-benzophenone hydrobromide. To a suspension of this hydrobromide in dry benzene (20 ml), 2-phthalimidoacetyl chloride (1.6 g) is added at room temperature. The resultant mixture is mixed with dry dimethylformamide (10 ml) and stirred at room temperature for 3 hours. The reaction mixture is poured into saturated aqueous sodium bicarbonate (50 ml)/water (50 ml) and stirred under ice-cooling for 30 minutes. The precipitate is filtered, washed with water and ether in order and dissolved in methylene chloride (about 50 ml). The organic layer is dried over magnesium sulfate and evaporated to remove the solvent. The residue is recrystallized from methylene chloride/ethanol to give 5-chloro-2-[3-(2-phthalimidoacetamidomethyl)-5-propargyloxymethyl-4H-1,2,4-triazol-4-yl]-benzophenone (682 mg) as crystals melting at 245° to 246° C. (decomp.).

Workup

  1. additionis added at room temperature
  2. stirringstirred under ice-
  3. temperaturecooling for 30 minutes
  4. filtrationThe precipitate is filtered
  5. washwashed with water and ether in order
  6. dissolutiondissolved in methylene chloride (about 50 ml)
  7. dry with materialThe organic layer is dried over magnesium sulfate
  8. customevaporated
  9. customto remove the solvent
  10. customThe residue is recrystallized from methylene chloride/ethanol

Sources & evidence

ORD record
ord-f34f936acbf34540ae06d8e1e481c6f9
Source dataset
uspto-grants-1979_03
Patent number
US04143048

Reaction notes

Loading…