Hydrochloric Acid → glycyl-L-phenylalanine benzyl ester hydrochloride

HRID 614202Notes

Reaction equation

HRID 614202 reaction equation
[CH2:1]([O:8][C:9](=[O:30])[C@H:10]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH:11][C:12](=[O:22])[CH2:13][NH:14]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>O1CCOCC1>[ClH:31].[CH2:1]([O:8][C:9](=[O:30])[C@H:10]([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[NH:11][C:12](=[O:22])[CH2:13][NH2:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 7408191HCID 7408191, compound

Product 1

HCID 70603822glycyl-L-phenylalanine benzyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

13.4 Parts N-t-butoxycarbonylglycyl-L-phenylalanine benzyl ester is dissolved in 200 parts dioxane and treated with a 10 fold excess of 2 N hydrochloric acid in dioxane for 10 minutes. Removal of the solvent under reduced pressure affords pure glycyl-L-phenylalanine benzyl ester hydrochloride.

Workup

  1. customRemoval of the solvent under reduced pressure

Sources & evidence

ORD record
ord-a147c1413df543ebb37d2a026621977a
Source dataset
uspto-grants-1979_03
Patent number
US04144228

Reaction notes

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