反应详情

To a stirred, cooled solution of 100 g. of 4-nitro-3-trifluoromethylaniline in 400 ml. of pyridine, slowly and in a dropwise fashion, add 54 g. of isobutyrylchloride and then heat the reaction mixture on a steam bath for 1.5 hours. Cool and pour the resulting mixture into ice-water, filter and water-wash the crude anilide, crystallize the product of this example from benzene to obtain analytically pure material, m.p. 111.5°-112.5° C.

1. temperatureTo a stirred, cooled solution of 100 g
2. temperatureCool
3. filtrationfilter
4. washwater-wash the crude anilide
5. customcrystallize the product of this example from benzene
6. customto obtain analytically pure material, m.p. 111.5°-112.5° C.