Ammonium Hydroxide → HCID 12445400, compound

HRID 614338Notes

Reaction equation

HRID 614338 reaction equation
[N+:1]([C:4]1[C:5]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[N:6][CH:7]=[C:8]([N+:10]([O-:12])=[O:11])[CH:9]=1)([O-])=O.[OH-].[NH4+]>C(O)C>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[NH:13][C:5]1[C:4]([NH2:1])=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 12445387N-(2-Fluorophenyl)-3,5-dinitropyridin-2-amine

Product 1

HCID 12445400HCID 12445400, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the product from Step A (1.0 g.) 15 ml. of ethanol and 5 ml. of concentrated ammonium hydroxide was warmed to 70° C. and hydrogen sulfide was bubbled in for 20 minutes. After cooling, the precipitate was collected and recrystallized from ethanol to give 2-(2-fluoroanilino)-3-amino-5-nitropyridine, m.p. 171°-172° C.

Workup

  1. customhydrogen sulfide was bubbled in for 20 minutes
  2. temperatureAfter cooling
  3. customthe precipitate was collected
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-f45c0cf662834a72af9a2dcbdb8caf92
Source dataset
uspto-grants-1979_03
Patent number
US04144341

Reaction notes

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