Sodium hydride → HCID 21329390, compound

HRID 614390Notes

Reaction equation

HRID 614390 reaction equation
[CH2:1]1[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[CH2:6][CH2:5][CH2:4][S:3][CH2:2]1.[H-].[Na+].[CH3:18][N:19]([CH3:24])[CH2:20][CH2:21][CH2:22]Cl>>[CH3:18][N:19]([CH3:24])[CH2:20][CH2:21][CH2:22][N:8]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=2[C:15]2[CH2:1][CH2:2][S:3][CH2:4][CH2:5][CH2:6][C:7]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 21329388HCID 21329388, compound

Product 1

HCID 21329390HCID 21329390, compound

Procedure

A mixture of 21.7g (0.1 mole) of 1,2,4,5,6,7-hexahydrothiocino-[5,4-b]indole, 4.29g (0.102 mole) of 57% dispersion sodium hydride and 12.16g (0.1 mole) of 3-dimethylaminopropyl chloride is treated according to the procedure in Example 6. Recrystallization from pentane affords 20.5g (68%) of an analytical sample, m.p. 70°-71° C.

Workup

  1. additionis treated
  2. customRecrystallization from pentane
  3. customaffords 20.5g (68%) of an analytical sample, m.p. 70°-71° C.

Sources & evidence

ORD record
ord-45fceb81f5e947c9ad2e78754690b9db
Source dataset
uspto-grants-1979_03
Patent number
US04144349

Reaction notes

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