Sodium hydride → HCID 21329394, compound

HRID 614391Notes

Reaction equation

HRID 614391 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[CH2:11][CH2:12][CH2:13][S:14](=[O:18])(=[O:17])[CH2:15][CH2:16][C:5]=3[C:4]=2[CH:3]=1.[H-].[Na+].[CH3:21][N:22]([CH3:27])[CH2:23][CH2:24][CH2:25]Cl>>[CH3:21][N:22]([CH3:27])[CH2:23][CH2:24][CH2:25][N:7]1[C:8]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=2[C:5]2[CH2:16][CH2:15][S:14](=[O:17])(=[O:18])[CH2:13][CH2:12][CH2:11][C:6]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 21329392HCID 21329392, compound

Product 1

HCID 21329394HCID 21329394, compound

Procedure

A mixture of 9.0g (0.0276 mole) of 1,2,4,5,6,7-hexahydro-10-bromothiocino[5,4-b]indole 3,3-dioxide, 1.3g (0.03 mole) of 57% dispersion sodium hydride and 3.36g (0.0276 mole) of 3-dimethylaminopropyl chloride is treated according to the procedure in Example 6. After recrystallization from ethyl acetate, there is obtained 6.0g (52%) of an analytical sample, m.p. 135°-137° C.

Workup

  1. additionis treated
  2. customAfter recrystallization from ethyl acetate
  3. customthere is obtained 6.0g (52%) of an analytical sample, m.p. 135°-137° C.

Sources & evidence

ORD record
ord-1f71092fa046494eb0b1d072c7c68f9e
Source dataset
uspto-grants-1979_03
Patent number
US04144349

Reaction notes

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