Ammonium Hydroxide → 1-Methyl-3-nitro-1H-pyrazole-4-carboxamide

HRID 614659Notes

Reaction equation

HRID 614659 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7](Cl)=[O:8])[C:4]([N+:10]([O-:12])=[O:11])=[N:3]1.[NH4+:13].[OH-]>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([NH2:13])=[O:8])[C:4]([N+:10]([O-:12])=[O:11])=[N:3]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 233295081-Methyl-3-nitro-1H-pyrazole-4-carbonyl chloride

Product 1

HCID 211619201-Methyl-3-nitro-1H-pyrazole-4-carboxamide

Procedure

Seven gm. of 1-methyl-3-nitro-4-pyrazolecarbonyl chloride was added in portions to 50 ml. of concentrated NH4OH. The mixture was heated at reflux for 15 to 20 minutes, evaporated to dryness, and cooled. The resultant crystallized product was identified as 1-methyl-3-nitro-4-pyrazolecarboxamide, m.p. 190°-192° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 15 to 20 minutes
  3. customevaporated to dryness
  4. temperaturecooled
  5. customThe resultant crystallized product

Sources & evidence

ORD record
ord-6b471832dc034e19acc5665c334a8142
Source dataset
uspto-grants-1979_03
Patent number
US04145554

Reaction notes

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