Trifluoroacetic acid → Trifluoroacetate

HRID 614781Notes

Reaction equation

HRID 614781 reaction equation
C([O:5][C:6](=[O:36])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:35])[CH:13]([CH2:30][S:31][C:32](=[O:34])[CH3:33])[CH2:14][CH2:15][CH2:16][NH:17]C(OCC1C=CC(OC)=CC=1)=O)(C)(C)C.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>C1(OC)C=CC=CC=1>[C:32]([S:31][CH2:30][CH:13]([CH2:14][CH2:15][CH2:16][NH2:17])[C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:36])=[O:5])=[O:35])(=[O:34])[CH3:33].[F:37][C:38]([F:43])([F:42])[C:39]([O-:41])=[O:40]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 228053291-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester

Product 2

HCID 84468TrifluoroacetateHCID 14181479HCID 14181479, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

1-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester (2 g) is dissolved in a mixture of trifluoroacetic acid (15 ml) and anisole (6 ml). The solution is stored at room temperature for one hour, the solvents are removed in vacuo and the residue is precipitated from ethyl acetate-ether to yield 1-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline, trifluoroacetate.

Workup

  1. customthe solvents are removed in vacuo
  2. customthe residue is precipitated from ethyl acetate-ether

Sources & evidence

ORD record
ord-1dbc5ea8709c4b6586869e5401601c03
Source dataset
uspto-grants-1979_03
Patent number
US04146611

Reaction notes

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