Dimethylformamide dimethyl acetal → HCID 70603237, compound

HRID 614801Notes

Reaction equation

HRID 614801 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:9]([CH3:23])[NH:8][C:7]=1[NH2:24])=[O:5])[CH3:2].CO[CH:27](OC)[N:28]([CH3:30])[CH3:29]>CCOCC>[CH2:1]([O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:9]([CH3:23])[NH:8][C:7]=1[N:24]=[CH:27][N:28]([CH3:30])[CH3:29])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 12391088HCID 12391088, compound

Product 1

HCID 70603237HCID 70603237, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

15 g (45 mmols) of 2-amino-4-phenyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester were warmed to 100° C. together with 10 g (84 mmols) of dimethylformamide dimethyl acetal and the mixture was stirred for about 60 minutes at this temperature. The reaction mass solidified whilst cooling and was suspended in a little ether, filtered off and recrystallised from ethanol. Melting point: 131° C. Yield: 13.7 g (79%)

Workup

  1. temperaturewhilst cooling
  2. filtrationfiltered off
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-fc10a3b4ee194ff5815b7fabcb69bc02
Source dataset
uspto-grants-1979_03
Patent number
US04146627

Reaction notes

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