反应详情

温度

25 °C

Benzyl chloroformate (5.5 g) was added to a suspension of 5-aminosalicylic acid (4.6 g) in dry pyridine (25 ml) at 0° C. during a period of 5 minutes. The mixture was allowed to warm to 25° C. and was stirred for 20 hours, and was then poured into a mixture of ice (100 g) and concentrated hydrochloric acid (50 ml). The solid that precipitated was then filtered off and dissolved in ethanol (50 ml) and treated with a little charcoal. The mixture was filtered and the filtrate was evaporated to dryness to give 5-benzyloxycarbonylaminosalicylic acid (2.2 g), m.p. 222°-224° C.

1. customThe solid that precipitated
2. filtrationwas then filtered off
3. dissolutiondissolved in ethanol (50 ml)
4. additiontreated with a little charcoal
5. filtrationThe mixture was filtered
6. customthe filtrate was evaporated to dryness