反应详情

A mixture of 5.1 g. 4-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-benzotriazole hydrochloride, 6.7 g. pivalic anhydride and 33.3 g. molten pivalic acid is stirred for 3 days at ambient temperature, then poured on to ice, neutralized with an aqueous solution of ammonia and extracted with methylene chloride. After evaporation of the extract, the oily residue obtained is taken up in methanol and rendered weakly acidic with dilute hydrochloric acid. Upon evaporating the solvent, there are obtained 2.53 g. (38% of theory) 4-[2-pivaloyloxy-3-(4-phenoxymethylpiperidino)-propoxy]-benzotriazole hydrochloride; m.p. 131°-133° C.

1. additionA mixture of 5.1 g
2. additionpoured on to ice
3. extractionextracted with methylene chloride
4. customAfter evaporation of the extract
5. customthe oily residue obtained
6. customUpon evaporating the solvent, there
7. customare obtained 2.53 g