Potassium Iodide → HCID 13090791, compound

HRID 615072Notes

Reaction equation

HRID 615072 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.[C-]#N.[K+].[I-].[K+].[CH3:20][N:21](C)C=O>O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13][C:20]#[N:21]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6228DimethylformamideHCID 9032Potassium CyanideHCID 13090784HCID 13090784, compound

Product 1

HCID 13090791HCID 13090791, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

49 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1), 13 parts of potassium cyanide and 0.1 part of potassium iodide in 300 parts of dimethylformamide were heated at 150° C. for 4 hours. Water was added to the reaction solution and the precipitated product was filtered off with suction and recrystallized from methylglycol. 32 parts of 3,7-dichloro-8-cyanomethylquinoline of melting point 152° C. were obtained. The yield corresponds to 67% of theory.

Workup

  1. filtrationthe precipitated product was filtered off with suction
  2. customrecrystallized from methylglycol

Sources & evidence

ORD record
ord-d4d9b9e65f8b456ebb1a61abe9d2ae5c
Source dataset
uspto-grants-1985_02
Patent number
US04497651

Reaction notes

Loading…