Ammonia → HCID 20429203, compound

HRID 615134Notes

Reaction equation

HRID 615134 reaction equation
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.N.C(OC(C1C(C2[N+:27]([O-:28])=[C:26]([CH3:29])[CH:25]=CC=2)C(C(OCC)=O)=C(C)NC=1C)=O)C>C(O)C>[CH3:29][C:26]1[CH:25]=[CH:5][CH:3]=[C:2]([CH:1]=[O:7])[N+:27]=1[O-:28]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 8868Ethyl AcetoacetateHCID 70490069HCID 70490069, compound

Product 1

HCID 20429203HCID 20429203, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to the process described in Example 1 there is obtained from 24.1 g of 2-methylpyridine-6-carboxaldehyde-1-oxide, 40 ml of ethanol, 50.4 ml of ethyl acetoacetate and 20 ml of 25% aqueous ammonia, 2,6-dimethyl-4-(2-methyl-1-oxido-6-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester which, after recrystallisation from ethanol, melts at 224°-225° (with decomposition).

Sources & evidence

ORD record
ord-e120f27f439549e5950a85ffe9ba1615
Source dataset
uspto-grants-1985_02
Patent number
US04497808

Reaction notes

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