Ammonia → HCID 20429200, compound

HRID 615140Notes

Reaction equation

HRID 615140 reaction equation
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.N.C(OC(C1[CH:21]([C:22]2[C:23](C)=[N+:24]([O-:28])C=CC=2)C(C(OCC)=O)=C(C)NC=1C)=O)C>C(O)C>[CH3:5][C:3]1[C:2]([CH:1]=[O:7])=[CH:21][CH:22]=[CH:23][N+:24]=1[O-:28]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 8868Ethyl AcetoacetateHCID 70489873HCID 70489873, compound

Product 1

HCID 20429200HCID 20429200, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to the process described in Example 1 there is obtained from 8.4 g of 2-methylpyridine-3-carboxaldehyde-1-oxide, 16.5 ml of ethyl acetoacetate and 6.1 ml of 30% aqueous ammonia in 34 ml of absolute ethanol, 2,6-dimethyl-4-(2-methyl-1-oxido-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester which, after recrystallisation from 600 ml of acetonitrile, melts at 228°-230°.

Sources & evidence

ORD record
ord-cc9d4b22687d4729987a3653628cdfde
Source dataset
uspto-grants-1985_02
Patent number
US04497808

Reaction notes

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