Ammonia → HCID 20429182, compound

HRID 615141Notes

Reaction equation

HRID 615141 reaction equation
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.N.C(OC(C1C(C2[C:23]([Cl:29])=[N+:24]([O-:28])[CH:25]=CC=2)C(C(OCC)=O)=C(C)NC=1C)=O)C>C(O)C>[Cl:29][C:23]1[C:2]([CH:1]=[O:7])=[CH:3][CH:5]=[CH:25][N+:24]=1[O-:28]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 8868Ethyl AcetoacetateHCID 86739906HCID 86739906, compound

Product 1

HCID 20429182HCID 20429182, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to the process described in Example 1 there is obtained from 8.4 g of 2-chloropyridine-3-carboxaldehyde-1-oxide, 12.75 ml of ethyl acetoacetate and 5 ml of 30% aqueous ammonia in 35 ml of absolute ethanol, 2,6-dimethyl-4-(2-chloro-1-oxido-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester which, after recrystallisation from 500 ml of isopropanol, melts at 255°-256°.

Sources & evidence

ORD record
ord-cdb7e0e7033943328fc4718495b84dee
Source dataset
uspto-grants-1985_02
Patent number
US04497808

Reaction notes

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