Methyl Isocyanate → HCID 135797530, compound

HRID 615301Notes

Reaction equation

HRID 615301 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][C:12]([CH:14]1[CH2:16][CH2:15]1)=O.[CH3:17][N:18]=[C:19]=[O:20]>C1COCC1>[CH:14]1([C:12]2([CH3:11])[N:18]([CH3:17])[C:19](=[O:20])[N:6]3[C:2](=[N:3][C:4]4[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=43)[NH:1]2)[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 12228Methyl IsocyanateHCID 13004Cyclopropyl methyl ketoneHCID 136242-Aminobenzimidazole

Product 1

HCID 135797530HCID 135797530, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Aminobenzimidazole, cyclopropyl methyl ketone and methyl isocyanate were reacted as in Example 26 using THF as a cosolvent with the excess ketone. Working up the reaction mixture gave none of the expected 10-N-methylcarbamoyl derivative of the title compound but, rather, the title compound itself, recrystallized from acetone to give a solid, mp 200° C. (dec.). The confirmatory elemental analysis is shown in Table III.

Sources & evidence

ORD record
ord-2e739232331f4790ba26227393a80a32
Source dataset
uspto-grants-1985_02
Patent number
US04498920

Reaction notes

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