Methacryloyl chloride → 12-[(2-Methylacryloyl)amino]dodecanoic acid

HRID 615425Notes

Reaction equation

HRID 615425 reaction equation
[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[CH2:3].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20].O1CCOCC1>O>[C:1]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:5])[C:2]([CH3:4])=[CH2:3]

Participants

5

Reactant 3

HCID 13528Methacryloyl chlorideHCID 312751,4-DioxaneHCID 6966112-Aminododecanoic Acid

Product 1

HCID 1938658512-[(2-Methylacryloyl)amino]dodecanoic acidYield 73%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.3 Mole of methacrylic acid chloride and 0.3 mole of 12-aminododecanoic acid were reacted in a mixed solvent of dioxane and water under Schotten Baumann reaction conditions to obtain N-methacryloyl-12-aminododecanoic acid in a yield of 73%.

Sources & evidence

ORD record
ord-28794f37e40843cbab20e55e18a8ce7a
Source dataset
uspto-grants-1985_02
Patent number
US04499251

Reaction notes

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