反应详情

A mixture of 1 g (5.55 mmoles) of 2,4-dihydroxy-3-propylacetophenone, 1.27 g (5.55 mmoles) of para-(β-bromoethyl)benzoic acid, 2.4 g of potassium carbonate, and 50 ml of dry acetone was stirred and refluxed for 3 days. The reaction flask was cooled and the stirred mixture was diluted with H2O and acidified with 6N HCl. Extraction with ethyl acetate and drying with Na2SO4 afforded the crude product after evaporating the ethyl acetate in vacuo. Pure 4-β-(4-acetyl-3-hydroxy-2-propylphenoxy)ethyl benzoic acid was isolated by flash chromatography on silica gel eluting with 5% MeOH/CH2Cl2 containing 0.1% acetic acid.

1. temperaturerefluxed for 3 days
2. temperatureThe reaction flask was cooled
3. extractionExtraction with ethyl acetate
4. dry with materialdrying with Na2SO4
5. customafforded the crude product
6. customafter evaporating the ethyl acetate in vacuo