Formic Acid → HCID 178507314, compound

HRID 615917Notes

Reaction equation

HRID 615917 reaction equation
COC1C=C(C([C:20]2[C:29]3[C:24](=[CH:25][C:26](OC)=[C:27](OC)[CH:28]=3)[CH:23]=[CH:22][N:21]=2)CC(OCC)OCC)C=CC=1OC.C(O)=O.Cl>CN(C)C=O>[N:21].[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][N:21]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 20406877HCID 20406877, compound

Product 1

HCID 178507314HCID 178507314, compoundYield 362.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7 g (0.0154 mole) of 1-[1-(3,4-dimethoxy-phenyl)-3,3-diethoxy-propyl]-6,7-dimethoxy-isoquinoline, prepared as described in example 7A, are refluxed at 160° C. for 16 hours in a mixture of 9 ml of dimethylformamide, 1.3 ml of 85% formic acid and 0.5 ml concentrated hydrochloric acid. After the reaction mixture has been concentrated under reduced pressure, it is made alkaline and extracted with benzene. 4 g of the title product are obtained, equivalent to a yield of 71.5%. m.p. 170° C.

Workup

  1. concentrationAfter the reaction mixture has been concentrated under reduced pressure, it
  2. extractionextracted with benzene

Sources & evidence

ORD record
ord-35198de69e6846df82d024ef9d3fea79
Source dataset
uspto-grants-1985_02
Patent number
US04501891

Reaction notes

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