Hydrogen Bromide → 4-(1-Ethylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

HRID 616030Notes

Reaction equation

HRID 616030 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[C:11]([O:17]C)[CH:10]=2)[CH2:4]1)[CH3:2].[BrH:19]>>[BrH:19].[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:17])[CH:10]=2)[CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 203708473-(3,4-Dimethoxyphenyl)-1-ethylpiperidine

Product 1

HCID 30463744-(1-Ethylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

Procedure

A mixture of 5.9 g of N-ethyl-3-(3',4'-dimethoxyphenyl)-piperidine and 30 ml of 66% hydrobromic acid was refluxed for an hour and was then evaporated to dryness under reduced pressure. The residue was crystallized from ethanol to obtain 5.9 g of N-ethyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide melting at 207° C.

Workup

  1. temperaturewas refluxed for an hour
  2. customwas then evaporated to dryness under reduced pressure
  3. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-a8158c60499246db98d207962ae5c7c2
Source dataset
uspto-grants-1978_02
Patent number
US04072685

Reaction notes

Loading…