Hydrogen Bromide → 4-(1-Propylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

HRID 616032Notes

Reaction equation

HRID 616032 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[C:12]([O:18]C)[CH:11]=2)[CH2:5]1)[CH2:2][CH3:3].[BrH:20]>>[BrH:20].[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([OH:18])[CH:11]=2)[CH2:5]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 11300035Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-

Product 1

HCID 30463764-(1-Propylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

Procedure

A mixture of 4 g of N-propyl-3-(3',4'-dimethoxyphenyl)-piperidine and 40 ml of 66% hydrobromic acid acid was refluxed for an hour and was then evaporated to dryness. The residue was crystallized from isopropanol to obtain 4.4 g of N-propyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide melting at 211° C.

Workup

  1. temperaturewas refluxed for an hour
  2. customwas then evaporated to dryness
  3. customThe residue was crystallized from isopropanol

Sources & evidence

ORD record
ord-8cd29e1503004a5e9b7e172c91c70ca8
Source dataset
uspto-grants-1978_02
Patent number
US04072685

Reaction notes

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