Acetyl chloride → HCID 20371016, compound

HRID 616091Notes

Reaction equation

HRID 616091 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([S:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[S:15].[C:21](Cl)(=[O:23])[CH3:22]>O1CCCC1>[C:21]([NH:1][C:2]1[CH:7]=[C:6]([S:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[S:15])(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 20371118HCID 20371118, compound

Product 1

HCID 20371016HCID 20371016, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.7 G. of 2-amino-4-n-butylthio-1-(3-methoxycarbonyl-2-thioureido)benzene is dissolved in 20 ml. tetrahydrofuran and treated with 1.5 ml. of acetyl chloride. The mixture is stripped after two hours and the residue recrystallized from methanol, yielding pure 2-acetamido-4-n-butylthio-1-(3-methoxycarbonyl-2-thioureido)benzene.

Workup

  1. customthe residue recrystallized from methanol

Sources & evidence

ORD record
ord-af11137e9cae46e491655a944e16f4f3
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

Loading…