Acetyl chloride → HCID 20371085, compound

HRID 616108Notes

Reaction equation

HRID 616108 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[NH:15][C:16]([NH:18][C:19]([O:21][CH3:22])=[O:20])=[S:17].[C:23](Cl)(=[O:25])[CH3:24]>O1CCCC1>[C:23]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[NH:15][C:16]([NH:18][C:19]([O:21][CH3:22])=[O:20])=[S:17])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 13166597HCID 13166597, compound

Product 1

HCID 20371085HCID 20371085, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.7 G. of 2-amino-1-(3-methoxycarbonyl-2-thioureido)-5- phenylthiobenzene, as prepared according to Example XI, is dissolved in 20 ml. tetrahydrofuran and treated with 1.5 ml. of acetyl chloride. The mixture is stripped after two hours and the residue recrystallized from methanol, yielding 2-acetamido-1-(3-methoxycarbonyl-2-thioureido)-5-phenylthiobenzene.

Workup

  1. dissolutionis dissolved in 20 ml
  2. customthe residue recrystallized from methanol

Sources & evidence

ORD record
ord-a7048ff058944db88b40070db82e12d7
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

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