反应详情

To a solution of 3.3 g (37.5 mmole) of pyruvic acid and 7.9 g (37.5 mmole) of trichloroethyl chloroformate in 20 ml of dry tetrahydrofuran at 0° is added dropwise 0.6 ml of pyridine. After stirring for 2 hours at room temperature, the mixture is concentrated in vacuum, diluted with water and extracted with ethyl acetate. The extract is washed with 5% HCl, dried over MgSO4, evaporated and distilled in vacuum to give 4.0 g (50%) trichloroethyl pyruvate, bp 75°-82° (17 mm).

1. concentrationthe mixture is concentrated in vacuum
2. additiondiluted with water
3. extractionextracted with ethyl acetate
4. washThe extract is washed with 5% HCl
5. dry with materialdried over MgSO4
6. customevaporated
7. distillationdistilled in vacuum