反应详情

To a solution of 1.00 g (8.06 mmol) of 2-pyrazinecarboxylic acid and 1.21 g (10.5 mmol) of N-hydroxysuccinimide in 70 ml of methylene-chloride, 1.85 g (9.67 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC) was added with stirring under ice-cooling, and the mixture was stirred at room temperature for 1 hour. Further, 1.94 g (8.06 mmol) of 4-(3-aminopropylthio)pyridine dihydrochloride was added, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate and water, and dried. The solvent was distilled off and the residue was purified by column chromatography (eluent: ethyl acetate) to give 0.751 g of the desired compound (34.0% yield, colorless powder).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 1 hour
3. stirringthe mixture was stirred at room temperature for 3 hours
4. washThe reaction mixture was washed with saturated aqueous sodium bicarbonate and water
5. customdried
6. distillationThe solvent was distilled off
7. customthe residue was purified by column chromatography (eluent: ethyl acetate)