1-Chloro-2-(diethylamine)ethane hydrochloride → Ethanamine, N,N-diethyl-2-(2-(2-methylpropoxy)phenoxy)-

HRID 616373Notes

Reaction equation

HRID 616373 reaction equation
[Na].[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[CH:3]([CH3:5])[CH3:4].Cl.[CH2:15]([N:17]([CH2:20][CH2:21]Cl)[CH2:18][CH3:19])[CH3:16]>C(O)C>[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:16][CH2:15][N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 6911612-IsobutoxyphenolHCID 5360545Sodium

Product 1

HCID 3042674Ethanamine, N,N-diethyl-2-(2-(2-methylpropoxy)phenoxy)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound was prepared as described in Example 1, using sodium (2.3 g; 100 mole), o-isobutoxyphenol (8.30 g; 50 mmole) and diethylaminoethylchloride hydrochloride (8.6 g; 50 mmole) in 150 ml of ethanol. Yield 9.3 g (70%) of product, boiling at 112° C under a pressure of 0.01 mm Hg, nD25 : 1.4942.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-b951a5f7c3754c21877343fa0b8cdfbc
Source dataset
uspto-grants-1978_02
Patent number
US04073917

Reaction notes

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