Piperidine, 1-(2-chloroethyl)-, hydrochloride → Piperidine, 1-(2-(2-butoxyphenoxy)ethyl)-

HRID 616375Notes

Reaction equation

HRID 616375 reaction equation
[Na].[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[CH2:3][CH2:4][CH3:5].Cl.[N:15]1([CH2:21][CH2:22]Cl)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>C(O)C>[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:22][CH2:21][N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 5360545SodiumHCID 12447746o-Butoxyphenol

Product 1

HCID 3042676Piperidine, 1-(2-(2-butoxyphenoxy)ethyl)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound was prepared as described in Example 1, using sodium (2.3 g, 100 mmole), o-butoxyphenol (8.30 g, 50 mmole) and piperidinoethylchloride hydrochloride (9.2 g, 50 mmole) in 150 ml of ethanol. Yield 4.4 g (32%) of product boiling at 121° C under a pressure of 0.02 mm Hg; nD25 1.5135.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-47436bb577754538ad72349319371715
Source dataset
uspto-grants-1978_02
Patent number
US04073917

Reaction notes

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