反应详情

To a suspension of 12.50 g (40 mmol) of 4-(4-phthalimidobutylthio)pyridine in 200 ml of ethanol, 5.82 ml (120 mmol) of hydrazine monohydrate was added, and the mixture was stirred at room temperature for 4 hours. Then, 200 ml of ethyl acetate was-added, and the insoluble material was filtered off. The volatile components were distilled off and chloroform was added to the residue. The mixture was washed with saturated saline and dried over potassium carbonate. The solvent was distilled off and 7.30 g of the desired compound were obtained (quantitative yield, yellow oil).

1. additionwas added
2. filtrationthe insoluble material was filtered off
3. distillationThe volatile components were distilled off
4. additionchloroform was added to the residue
5. washThe mixture was washed with saturated saline
6. dry with materialdried over potassium carbonate
7. distillationThe solvent was distilled off