反应详情

Formaldehyde (75 ml of 40% solution) was added to a stirred solution of cyanacetic acid (43g) and piperidine (85g) in water at 15° C. The solution was stirred for 1 hour at room temperature and then boiled under reflux for 2 hours. On cooling the reaction mixture separated into two layers, the top layer was separated and distilled to give a colourless oil, boiling point 117°-118° C 0.5mm.

1. temperatureunder reflux for 2 hours
2. temperatureOn cooling the reaction mixture
3. customseparated into two layers
4. customthe top layer was separated
5. distillationdistilled
6. customto give a colourless oil, boiling point 117°-118° C 0.5mm