Hydrogen Peroxide → HCID 20367579, compound

HRID 616504Notes

Reaction equation

HRID 616504 reaction equation
[NH2:1][C:2]([N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)=[C:3]([C:7]#[N:8])[C:4](=[S:6])[NH2:5].OO>>[NH2:5][C:4]1[S:6][N:1]=[C:2]([N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[C:3]=1[C:7]#[N:8]

Participants

3

Reactant 2

HCID 784Hydrogen PeroxideHCID 85942030HCID 85942030, compound

Product 1

HCID 20367579HCID 20367579, compoundYield 88.1%

Procedure

Using the procedure of Example I, part F, 81.7 g of 3-amino-2-cyano-3-(1-pyrrolidinyl)propenethioamide were oxidized with 48 ml of 30% hydrogen peroxide to give 71.2 g of 5-amino-4-cyano-3-(1-pyrrolidinyl)isothiazole, m.p. 198°. The nmr spectrum was consistent with the assigned structure.

Sources & evidence

ORD record
ord-a702880a3c2448678fd4e1cac4dfa48a
Source dataset
uspto-grants-1978_02
Patent number
US04075001

Reaction notes

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