Phenacyl bromide → 2-Chloro-5-(2-oxo-2-phenylethyl)-5H-thieno[3,2-c]pyridin-1-ium bromide

HRID 616589Notes

Reaction equation

HRID 616589 reaction equation
[Cl:1][C:2]1[S:10][C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=1.[CH2:11]([Br:20])[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]>>[Br-:20].[Cl:1][C:2]1[S:10][C:9]2[CH:8]=[CH:7][N+:6]([CH2:11][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:13])=[CH:5][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 6259Phenacyl bromideHCID 5981922-Chlorothieno[3,2-c]pyridine

Product 1

HCID 30413172-Chloro-5-(2-oxo-2-phenylethyl)-5H-thieno[3,2-c]pyridin-1-ium bromideYield 80.1%

Procedure

Reaction of 2-chloro-thieno[3,2-c]pyridine (17 g) with phenacyl bromide (20 g) according to the procedure of Example 1 gives white crystals (29.60 g) having a melting point (Koefler block of 239° C.

Sources & evidence

ORD record
ord-7831469e428742619ff225c0994849b5
Source dataset
uspto-grants-1978_02
Patent number
US04075215

Reaction notes

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