Sodium hydride → Dipropylaminopropyl chloride

HRID 616592Notes

Reaction equation

HRID 616592 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[NH:13][NH:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:6]=2[CH:24]=1.[H-].[Na+]>>[CH2:8]([N:7]([CH2:6][CH2:24][CH2:2][Cl:1])[CH2:17][CH2:18][CH3:19])[CH2:9][CH3:10].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]([CH2:4][CH2:5][CH2:6][N:7]([CH2:17][CH2:18][CH3:19])[CH2:8][CH2:9][CH3:10])[NH:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:6]=2[CH:24]=1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 203679348-chloro-6-(o-chlorophenyl)-1H-s-triazolo[4,3-a][1,5]benzodiazepin-1,5-(2H,6H)-dione

Product 2

HCID 12333917Dipropylaminopropyl chlorideHCID 203680218-chloro-2-[(dipropylamino)propyl]-6-(o-chlorophenyl)-1H-s-triazolo[4,3-a][1,5]benzodiazepin-1,5-(2H,6H)-dione

Procedure

In the manner given in Example 21, 8-chloro-6-(o-chlorophenyl)-1H-s-triazolo[4,3-a][1,5]benzodiazepin-1,5-(2H,6H)-dione can be reacted with sodium hydride and then with dipropylamino propyl chloride to give 8-chloro-2-[(dipropylamino)propyl]-6-(o-chlorophenyl)-1H-s-triazolo[4,3-a][1,5]benzodiazepin-1,5-(2H,6H)-dione.

Sources & evidence

ORD record
ord-b2f332cf91ce4c4585cc0985da87b799
Source dataset
uspto-grants-1978_02
Patent number
US04075202

Reaction notes

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