HCID 20368141, compound → HCID 20368148, compound

HRID 616667Notes

Reaction equation

HRID 616667 reaction equation
[Cl:1][C:2]1[C:7]2[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])=[N:9][CH2:10][C:11]3[N:12]([C:13]([CH3:16])=[N:14][N:15]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1>CN(C)C=O.CN(CN(C)C)C.C(Cl)(=O)C>[Cl:1][C:2]1[C:7]2[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])=[N:9][CH2:10][C:11]3[N:12]([C:13]([CH2:16][CH2:11][N:12]([CH3:13])[CH3:6])=[N:14][N:15]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 1

HCID 20368141HCID 20368141, compound

Product 1

HCID 20368148HCID 20368148, compound

Reagents, catalysts & solvents 3

HCID 5829N,N,N',N'-TetramethylmethanediamineSolvent2×HCID 6228DimethylformamideSolventHCID 6367Acetyl chlorideSolvent

Procedure

In the manner given in Example 1, a solution of 7-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetramethyldiaminomethane and acetyl chloride (in 0.25 molar excess compared to the N,N,N',N'-tetramethyldiaminomethane) are reacted together to give 7-chloro-1-[2-(dimethylamino)ethyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-b7798d3646974557b4fb4311a62d080d
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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