HCID 19010444, compound → HCID 20368140, compound

HRID 616669Notes

Reaction equation

HRID 616669 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH3:16])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:7]=2[CH:23]=1>CN(C)C=O.CN(CN(C)C)C.C(Cl)(=O)C>[F:25][C:2]([F:24])([F:1])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][CH2:11][N:12]([CH3:13])[CH3:6])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:7]=2[CH:23]=1

Participants

5

Reactant 1

HCID 19010444HCID 19010444, compound

Product 1

HCID 20368140HCID 20368140, compound

Reagents, catalysts & solvents 3

HCID 5829N,N,N',N'-TetramethylmethanediamineSolvent2×HCID 6228DimethylformamideSolventHCID 6367Acetyl chlorideSolvent

Procedure

In the manner given in Example 1, a solution of 8-trifluoromethyl-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetramethyldiaminomethane and acetyl chloride (in 0.1 molar excess compared to the N,N,N', N'-tetramethyldiaminomethane) are reacted together to give 8-trifluoromethyl-1-[2-(dimethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-6c42e22ffec64243b62350e69926640d
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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