Acetyl chloride → HCID 20368144, compound

HRID 616670Notes

Reaction equation

HRID 616670 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH3:16])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:7]=2[CH:23]=1.[C:26](Cl)(=O)[CH3:27]>CN(C)C=O>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][CH2:11][N:12]([CH2:13][CH2:26][CH3:27])[CH2:6][CH2:5][CH3:4])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:7]=2[CH:23]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 20368138HCID 20368138, compound

Product 1

HCID 20368144HCID 20368144, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner given in Example 1, a solution of 8-trifluoromethyl-1-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetrapropyldiaminomethane and acetyl chloride (in 0.1 molar excess compared to the N,N,N',N'-tetrapropyldiaminomethane) are reacted together to give 8-trifluoromethyl-1-[2-(dipropylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4-]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-718ee3becdf949c89550cacef1cd00f4
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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