Trifluoroacetic anhydride → HCID 20368143, compound

HRID 616672Notes

Reaction equation

HRID 616672 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH3:16])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:7]=2[CH:23]=1.FC(F)(F)C(O[C:29](=O)[C:30](F)(F)F)=O>CN(C)C=O>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][CH2:11][N:12]([CH2:13][CH2:29][CH3:30])[CH2:6][CH2:5][CH3:4])=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:7]=2[CH:23]=1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 20368152HCID 20368152, compound

Product 1

HCID 20368143HCID 20368143, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner given in Example 1, a solution of 8-methylthio-1-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetrapropyldiaminomethane and trifluoroacetic anhydride (in 0.2 molar excess compared to the N,N,N',N'-tetrapropyldiaminomethane) are reacted together to give 8-methylthio-1-[2-(dipropylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-62c5ecc7b16844d78ea746b5ebea074e
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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