Hydrochloric Acid → HCID 20300269, compound

HRID 616693Notes

Reaction equation

HRID 616693 reaction equation
N[C@H](C([NH:11][C:12]([NH2:14])=[O:13])=O)CC1SC=CC=1.[N:15]1[CH:16]=[N:17][N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]=12.[OH-].[Na+].OO.Cl>>[NH:11]([C:16]1[N:15]=[C:19]2[C:20]3[C:25]([CH2:26][CH2:27][N:18]2[N:17]=1)=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:12]([NH2:14])=[O:13]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 131711036HCID 131711036, compound

Product 1

HCID 20300269HCID 20300269, compound

Conditions

Temperature
80 °C

Procedure

2-Thiureido-5,6-dihydro-s-triazolo[5,1-a]isoquinoline (1.2 g.) is suspended in 20 ml. of 2% aqueous sodium hydroxide and 1.9 ml. of 30% H2O2 is added at 40°-45° C. After 15 minutes, the mixture is heated for 5 minutes at 80° C and, after cooling and neutralizing with dilute hydrochloric acid, the solid precipitate is recovered by filtration and purified by crystallization from 70% ethanol. Yield 0.8 g.; m.p. 210°-2° C.

Workup

  1. filtrationthe solid precipitate is recovered by filtration
  2. custompurified by crystallization from 70% ethanol

Sources & evidence

ORD record
ord-4a108d79d7a84cb2b6420d00adc14bec
Source dataset
uspto-grants-1978_02
Patent number
US04075341

Reaction notes

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