Oxalyl chloride → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonyl chloride

HRID 616949Notes

Reaction equation

HRID 616949 reaction equation
[O:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15]([OH:17])=O)[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[Na].C(Cl)(=O)C([Cl:22])=O>C1C=CC=CC=1>[O:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15]([Cl:22])=[O:17])[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1

Participants

5

Reactant 3

HCID 65578Oxalyl chlorideHCID 5360545SodiumHCID 1354968195,6-Dihydro-5-oxo-pyrazolo(1,5-c)quinazoline-2-carboxylic acid

Product 1

HCID 1357356245,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4.8 g (0.019 mole) of 5,6-dihydro-5-oxopyrazolo[1,5-c]-quinazoline-2-carboxylic acid, sodium salt is added to a solution of 3.27 g (0.026 mole) of oxalyl chloride in 200 ml of benzene. The suspension is stirred at room temperature for 20 minutes and then refluxed under nitrogen for 2 hours. The solvent is stripped to give the product.

Workup

  1. temperaturerefluxed under nitrogen for 2 hours
  2. customto give the product

Sources & evidence

ORD record
ord-04f2ac1286744cfa971952de13d561cb
Source dataset
uspto-grants-1978_02
Patent number
US04076818

Reaction notes

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