Hydrochloric Acid → HCID 135737565, compound

HRID 616957Notes

Reaction equation

HRID 616957 reaction equation
[OH:1][C:2]1[C:3]2[C:4]3[N:5]([N:13]=[C:14]([CH2:16][OH:17])[CH:15]=3)[C:6](=[O:12])[NH:7][C:8]=2[CH:9]=[CH:10][CH:11]=1.[CH3:18]I.Cl>[Na].CO>[OH:17][CH2:16][C:14]1[CH:15]=[C:4]2[N:5]([C:6](=[O:12])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[C:2]([O:1][CH3:18])[C:3]=32)[N:13]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 135737578HCID 135737578, compound

Product 1

HCID 135737565HCID 135737565, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 5360545SodiumSolvent

Procedure

To 4.2 g of 10-hydroxy-2-(hydroxymethyl)pyrazolo[1,5-c]-quinazoline-5(6H)-one in a solution of 0.58 g sodium dissolved in 100 ml dry methanol is added 2.9 g of methyl iodide. After stirring for 3 hours at 50°, the reaction is neutralized with one equivalent of 1N hydrochloric acid, evaporated and the residue recrystallized from absolute ethanol to give the title compound.

Workup

  1. customevaporated
  2. customthe residue recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-408839cde26345998a9fdf3172cecdb1
Source dataset
uspto-grants-1978_02
Patent number
US04076818

Reaction notes

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