Piperazine → 1-Undecylpiperazine

HRID 617117Notes

Reaction equation

HRID 617117 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 127441-Bromoundecane

Product 1

HCID 129309111-Undecylpiperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.

Workup

  1. customto react overnight
  2. extractionThe mixture is extracted with aqueous sodium bicarbonate
  3. dry with materialthe organic layer dried with sodium sulfate
  4. filtrationThe mixture is filtered
  5. customthe solvent removed in vacuo
  6. customthe residue purified by column chromatography

Sources & evidence

ORD record
ord-1699726efc0f411d92dacde0e031d07a
Source dataset
uspto-grants-1999_09
Patent number
US05948753

Reaction notes

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