反应详情

To an ice-cold solution of 2-amino-4-(4-piperidyl)quinazoline (500 mg, 2.19 mmol) and triethylamine (233 mg, 2.3 mmol) in N,N-dimethylformamide (10 ml) was added dropwise acetic anhydride (0.22 ml, 2.30 mmol) under a nitrogen atmosphere. The reaction mixture was stirred for about 3 hours and was evaporated. The residue was partitioned between dichloromethane and saturated sodium hydrogencarbonate aqueous solution. The organic layer was washed with water and then dried over sodium sulfate and evaporated in vacuo. The residue was crystallized from ethanol. Recrystallization from methanol gave the titled compound(452 mg).

1. customwas evaporated
2. customThe residue was partitioned between dichloromethane and saturated sodium hydrogencarbonate aqueous solution
3. washThe organic layer was washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated in vacuo
6. customThe residue was crystallized from ethanol
7. customRecrystallization from methanol