Hydrochloric Acid → HCID 9928264, compound

HRID 617242Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[C:11]3([CH2:15][C:14](=O)[NH:13][C:12]3=O)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[C:11]3([CH2:15][CH2:14][NH:13][CH2:12]3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21852126HCID 21852126, compound

Product 1

HCID 9928264HCID 9928264, compound

Procedure

Using a procedure similar to that described in Example 3, except replacing the 1a used therein with the 1c, the title compound was prepared; 1H NMR (free base) (CDCl3): δ 1.40-2.05 (m, 4H, CH2), 2.45 (m, 2H, CH2), 2.98-3.65 (m, 3H, CH2 and NH), 3.80 (s, 3H, OCH3),4.28 (t, 1H, CH), 6.71-6.81 (m, 3H, Ar--H), 7.0 (d, 1H, Ar--H), 7.21-7.38 (m, 2H, Ar--H). Elemental analysis calcd. for Cl19H19Cl2NO.HCl: C, 59.52; H, 5.26; N, 3.66. Found: C, 59.61; H, 5.57; 2.95.

Sources & evidence

ORD record: ord-870e75a6cfe54daeb515cadc3058cab2
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948807

Reaction notes

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