反应详情

温度

25 °C

To a solution of 7-cyano-5-nitroindole (0.7 g, 4.4 mmol) in 20 mL of THF was added 5.0 mL of MeMgBr (3.0 M) and the resulting reaction mixture was stirred for 12 h at 25° C. Reaction was quenched by adding 10 mL of 1.0 N aqueous HCl. Reaction mixture was basified with 3 N aqueous NaOH and aqueous solution was extracted with EtOAc several times. Organic extracts were dried over MgSO4 and concentrated in vacuo to provide oily residue which was subjected to column chromatography (50% EtOAc/Cy.hexane) to yield 0.20 g (1.2 mmol, 26%) of the desired product.

1. customthe resulting reaction mixture
2. customReaction
3. customwas quenched
4. additionby adding 10 mL of 1.0 N aqueous HCl
5. customReaction mixture
6. extractionwas extracted with EtOAc several times
7. dry with materialOrganic extracts were dried over MgSO4
8. concentrationconcentrated in vacuo
9. customto provide oily residue which