Hydrochloric Acid → HCID 67585873, compound

HRID 617351Notes

Reaction equation

HRID 617351 reaction equation
[F:1][C@@H:2]1[CH2:6][N:5]([CH3:7])[C@H:4]([CH2:8][O:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:3]1.[ClH:16]>CCOCC>[ClH:16].[ClH:16].[F:1][C@@H:2]1[CH2:6][N:5]([CH3:7])[C@H:4]([CH2:8][O:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54319796HCID 54319796, compound

Product 1

HCID 67585873HCID 67585873, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound from step 78a above was treated with HCl in ether according to Example 14c to afford 20 mg of the title compound. MS (DCI/NH3) m/e: 211 (M+H)+. 1H NMR (CD3OD, 300 MHz) δ: 8.77 (d, J=2.6 Hz, 1H), 8.57 (d, J=5.5 Hz, 1H), 8.37 (m, 1H), 8.08 (m, 1H, 5.60-5.40 (m, 1H), 4.72 (m, 1H), 4.58 (m, 1H), 4.21 (m, 1H), 4.04 (m, 1H), 3.65-3.47 (m, 1H), 3.19 (s, 3H), 3.02-2.80 (m, 1H), 2.43-2.28 (m, 1H). Anal. Calc. for C11H15N2OF.2.4 HCl.0.2 H2O: C, 43.84; H, 5.95; N, 9.29; Found C, 43.47; H, 5.88; N, 8.98.

Sources & evidence

ORD record
ord-e8c0c216d1e442a783b7b8f9cfe4695d
Source dataset
uspto-grants-1999_09
Patent number
US05948793

Reaction notes

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