反应详情

To a solution of sodium ethoxide (10.8 g) in ethanol (500 ml), 2-(2-hydroxyphenyl)ethanol (20.0 g) and benzyl bromide (24.8 g) were added and the mixture was refluxed under heating for 2 hours. The solvent was distilled away under reduced pressure, water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with a 2M aqueous potassium hydroxide solution and a saturated brine and dried over sodium sulfate. The solvent was distilled away under reduced pressure and the residue was subjected to silica gel chromatography (eluent; hexane-ethyl acetate=8:1) to give the subject compound (27.2 g).

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 2 hours
3. distillationThe solvent was distilled away under reduced pressure, water
4. additionwas added
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with a 2M aqueous potassium hydroxide solution
7. dry with materiala saturated brine and dried over sodium sulfate
8. distillationThe solvent was distilled away under reduced pressure